Deciphering the transcriptional cis-regulatory code in cell fate decisions
The regulation of gene expression in response to developmental or environmental stimuli is a fundamental process in all mammalian cells. Our main goal is to elucidate the detailed mechanisms of transcriptional regulation, with a particular interest in the interplay between cis-regulatory elements and trans-acting factors, and their implications in gene transcription and cell fate decisions.
Major research directions:
To achieve these goals, we use a wide range of cutting-edge technologies, including deep learning, bioinformatics, genomics, CRISPR gene editing, high-throughput screening, and next generation sequencing techniques (such as STARR-Seq、Hi-C、ATAC-Seq、ChIP-Seq、RNA-Seq and so on).